Trajectory of Metabolic Syndrome Severity and Risk of Chronic Kidney Disease
A trajectory of persistently high metabolic syndrome severity significantly increases the likelihood of developing chronic kidney disease (CKD), a new longitudinal analysis finds.
Study Overview
Researchers led by Ladan Mehran, M.D., Ph.D., at Shahid Beheshti University of Medical Sciences in Tehran evaluated 4,462 adults aged 20 to 60 who were free of CKD at baseline. Participants were assessed every three years; metabolic syndrome severity—measured by the continuous metabolic syndrome severity score (cMetS-S)—was tracked from 1999 to 2009, and incident CKD was then monitored from 2010 through 2018.
Findings on cMetS-S Trajectories
Three distinct cMetS-S trajectory groups emerged during the exposure period: low (28.3%), medium (50.0%), and high (21.7%). After controlling for age, sex, education, smoking, physical activity, and baseline estimated glomerular filtration rate, individuals in the high-severity trajectory had a higher risk of developing CKD (hazard ratio, 1.32). This association persisted after additional adjustment for the individual components of metabol...